
Statistician
+1 415 514-8028
Dr. Kornak received his BSc in Mathematics with Statistics (1996) and Ph.D. in Statistics (2000) from the University of Nottingham, UK. He spent time as a postdoc at UCSF and The Ohio State University before joining the Department of Radiology and Biomedical Imaging at UCSF in 2003. He transferred to Epidemiology and Biostatistics in July 2010 and is currently the Head of the Data Science Program and the Director of the CTSI Biostatistical Consulting Unit.
Honors and Awards
Fellow, American Statistical Association, 2024
Excellence Award, UCSF CTSI Consultant of the Year Award, 2011
Impact Award, UCSF CTSI Consultant of the Year Award, 2010
Consistent Excellence Award, UCSF CTSI Consultant of the Year Award, 2009
Elected Fellow, Royal Statistical Society, 1999
Publications
Detection Bias in EHR-Based Research on Clinical Exposures and Dementia.
JAMA network open
Sex differences in the clinical manifestation of autosomal dominant frontotemporal dementia.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Hyperorality in Frontotemporal Dementia: How Psychiatric and Neural Correlates Change During the Disease Course.
The Journal of neuropsychiatry and clinical neurosciences
Neuropsychiatric symptoms cluster and fluctuate over time in behavioral variant frontotemporal dementia.
Psychiatry and clinical neurosciences
MRI-Based Model for Personalizing Neoadjuvant Treatment in Breast Cancer.
Tomography (Ann Arbor, Mich.)
Associations between local COVID-19 policies and anxiety in the USA: a longitudinal digital cohort study.
BMJ public health
Brain aging rejuvenation factors in adults with genetic and sporadic neurodegenerative disease.
Brain communications
Tumor Morphology for Prediction of Poor Responses Early in Neoadjuvant Chemotherapy for Breast Cancer: A Multicenter Retrospective Study.
Tomography (Ann Arbor, Mich.)
MRI-Based Multi-Class Relevance Vector Machine Classification of Neurodegenerative Diseases.
medRxiv : the preprint server for health sciences
Neuropsychiatric Symptoms Cluster and Fluctuate Over Time in Behavioral Variant Frontotemporal Dementia.
medRxiv : the preprint server for health sciences
Sex-stratified analyses of comorbidities associated with an inpatient delirium diagnosis using real world data.
Research square
Gene specific effects on brain volume and cognition of TMEM106B in frontotemporal lobar degeneration.
medRxiv : the preprint server for health sciences
Reliability and Validity of Smartphone Cognitive Testing for Frontotemporal Lobar Degeneration.
JAMA network open
Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration.
Research square
18F-FDG Dedicated Breast PET Complementary to Breast MRI for Evaluating Early Response to Neoadjuvant Chemotherapy.
Radiology. Imaging cancer
Effect of Longitudinal Variation in Tumor Volume Estimation for MRI-guided Personalization of Breast Cancer Neoadjuvant Treatment.
Radiology. Imaging cancer
Feasibility and acceptability of remote smartphone cognitive testing in frontotemporal dementia research.
Alzheimer's & dementia (Amsterdam, Netherlands)
Plasma inflammation for predicting phenotypic conversion and clinical progression of autosomal dominant frontotemporal lobar degeneration.
Journal of neurology, neurosurgery, and psychiatry
Factors Associated With Long COVID Symptoms in an Online Cohort Study.
Open forum infectious diseases
Multisite ALLFTD study modeling progressive empathy loss from the earliest stages of behavioral variant frontotemporal dementia.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Factors Associated with Long Covid Symptoms in an Online Cohort Study.
medRxiv : the preprint server for health sciences
Temporal order of clinical and biomarker changes in familial frontotemporal dementia.
Nature medicine
Diffusion-Weighted MRI for Predicting Pathologic Complete Response in Neoadjuvant Immunotherapy.
Cancers
Detection of emerging neurodegeneration using Bayesian linear mixed-effect modeling.
NeuroImage. Clinical
Proposed research criteria for prodromal behavioural variant frontotemporal dementia.
Brain : a journal of neurology
Effect of Inter-Reader Variability on Diffusion-Weighted MRI Apparent Diffusion Coefficient Measurements and Prediction of Pathologic Complete Response for Breast Cancer.
Tomography (Ann Arbor, Mich.)
Post-Processing Bias Field Inhomogeneity Correction for Assessing Background Parenchymal Enhancement on Breast MRI as a Quantitative Marker of Treatment Response.
Tomography (Ann Arbor, Mich.)
The contribution of behavioral features to caregiver burden in FTLD spectrum disorders.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Recognition memory and divergent cognitive profiles in prodromal genetic frontotemporal dementia.
Cortex; a journal devoted to the study of the nervous system and behavior
Association of a Proposed New Staging System for Folliculotropic Mycosis Fungoides With Prognostic Variables in a US Cohort.
JAMA dermatology
Evaluation of primary breast cancers using dedicated breast PET and whole-body PET.
Scientific reports
Brain volumetric deficits in MAPT mutation carriers: a multisite study.
Annals of clinical and translational neurology
Predicting breast cancer response to neoadjuvant treatment using multi-feature MRI: results from the I-SPY 2 TRIAL.
NPJ breast cancer
Development and validation of the Uniform Data Set (v3.0) executive function composite score (UDS3-EF).
Alzheimer's & dementia : the journal of the Alzheimer's Association
Rates of Brain Atrophy Across Disease Stages in Familial Frontotemporal Dementia Associated With MAPT, GRN, and C9orf72 Pathogenic Variants.
JAMA network open
Predictive Value of Breast MRI Background Parenchymal Enhancement for Neoadjuvant Treatment Response among HER2- Patients.
Journal of breast imaging
Quality of life and caregiver burden in familial frontotemporal lobar degeneration: Analyses of symptomatic and asymptomatic individuals within the LEFFTDS cohort.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Impact of MRI Protocol Adherence on Prediction of Pathological Complete Response in the I-SPY 2 Neoadjuvant Breast Cancer Trial.
Tomography (Ann Arbor, Mich.)
Tumor Sphericity Predicts Response in Neoadjuvant Chemotherapy for Invasive Breast Cancer.
Tomography (Ann Arbor, Mich.)
Revised Self-Monitoring Scale: A potential endpoint for frontotemporal dementia clinical trials.
Neurology
Clinical and volumetric changes with increasing functional impairment in familial frontotemporal lobar degeneration.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Individualized atrophy scores predict dementia onset in familial frontotemporal lobar degeneration.
Alzheimer's & dementia : the journal of the Alzheimer's Association
The longitudinal evaluation of familial frontotemporal dementia subjects protocol: Framework and methodology.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Use of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Active lifestyles moderate clinical outcomes in autosomal dominant frontotemporal degeneration.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Assessment of executive function declines in presymptomatic and mildly symptomatic familial frontotemporal dementia: NIH-EXAMINER as a potential clinical trial endpoint.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Comparison of sporadic and familial behavioral variant frontotemporal dementia (FTD) in a North American cohort.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Genetic screening of a large series of North American sporadic and familial frontotemporal dementia cases.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Nonlinear Z-score modeling for improved detection of cognitive abnormality.
Alzheimer's & dementia (Amsterdam, Netherlands)
Effect of Collaborative Dementia Care via Telephone and Internet on Quality of Life, Caregiver Well-being, and Health Care Use: The Care Ecosystem Randomized Clinical Trial.
JAMA internal medicine
Tracking white matter degeneration in asymptomatic and symptomatic MAPT mutation carriers.
Neurobiology of aging
Neuropathological correlates of structural and functional imaging biomarkers in 4-repeat tauopathies.
Brain : a journal of neurology
The costs of dementia subtypes to California Medicare fee-for-service, 2015.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Additive value of diffusion-weighted MRI in the I-SPY 2 TRIAL.
Journal of magnetic resonance imaging : JMRI
Longitudinal multimodal imaging and clinical endpoints for frontotemporal dementia clinical trials.
Brain : a journal of neurology
Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory.
Annals of clinical and translational neurology
Exploration of PET and MRI radiomic features for decoding breast cancer phenotypes and prognosis.
NPJ breast cancer
Thalamic atrophy in multiple sclerosis: A magnetic resonance imaging marker of neurodegeneration throughout disease.
Annals of neurology
The Rural Inpatient Mortality Study: Does Urban-Rural County Classification Predict Hospital Mortality in California?
The Permanente journal
Clinicopathological correlations in behavioural variant frontotemporal dementia.
Brain : a journal of neurology
Characterization and stratification of prostate lesions based on comprehensive multiparametric MRI using detailed whole-mount histopathology as a reference standard.
NMR in biomedicine
Longitudinal white matter change in frontotemporal dementia subtypes and sporadic late onset Alzheimer's disease.
NeuroImage. Clinical
Associations of Body Mass Index and Body Fat With Markers of Inflammation and Nutrition Among Patients Receiving Hemodialysis.
American journal of kidney diseases : the official journal of the National Kidney Foundation
Data-driven regions of interest for longitudinal change in three variants of frontotemporal lobar degeneration.
Brain and behavior
Effect of MR Imaging Contrast Thresholds on Prediction of Neoadjuvant Chemotherapy Response in Breast Cancer Subtypes: A Subgroup Analysis of the ACRIN 6657/I-SPY 1 TRIAL.
Tomography (Ann Arbor, Mich.)
Out-of-Network Emergency Department Use among Managed Medicaid Beneficiaries.
Health services research
Age-dependent effects of APOE ε4 in preclinical Alzheimer's disease.
Annals of clinical and translational neurology
Improving Screening Mammography Outcomes Through Comparison With Multiple Prior Mammograms.
AJR. American journal of roentgenology
Variability and bias assessment in breast ADC measurement across multiple systems.
Journal of magnetic resonance imaging : JMRI
Association of Self-Reported Frailty with Falls and Fractures among Patients New to Dialysis.
American journal of nephrology
Data-driven regions of interest for longitudinal change in frontotemporal lobar degeneration.
NeuroImage. Clinical
Biomarkers and cognitive endpoints to optimize trials in Alzheimer's disease.
Annals of clinical and translational neurology
Associations of Trimethylamine N-Oxide With Nutritional and Inflammatory Biomarkers and Cardiovascular Outcomes in Patients New to Dialysis.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation
Gradient nonlinearity correction to improve apparent diffusion coefficient accuracy and standardization in the american college of radiology imaging network 6698 breast cancer trial.
Journal of magnetic resonance imaging : JMRI
Predicting amyloid status in corticobasal syndrome using modified clinical criteria, magnetic resonance imaging and fluorodeoxyglucose positron emission tomography.
Alzheimer's research & therapy
Odanacatib treatment affects trabecular and cortical bone in the femur of postmenopausal women: results of a two-year placebo-controlled trial.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Depression is not associated with peripheral insulin resistance in patients with chronic hepatitis C infection.
Journal of viral hepatitis
In vivo evidence of glutamate toxicity in multiple sclerosis.
Annals of neurology
Magnetic resonance spectroscopy markers of disease progression in multiple sclerosis.
JAMA neurology
Comparison of self-report-based and physical performance-based frailty definitions among patients receiving maintenance hemodialysis.
American journal of kidney diseases : the official journal of the National Kidney Foundation
Calibration of the brief food frequency questionnaire among patients on dialysis.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation
Real-Time Measurement of Functional Tumor Volume by MRI to Assess Treatment Response in Breast Cancer Neoadjuvant Clinical Trials: Validation of the Aegis SER Software Platform.
Translational oncology
Repeatability of quantitative MRI measurements in normal breast tissue.
Translational oncology
Application of quantitative DTI metrics in sporadic CJD.
NeuroImage. Clinical
Aggressive and minimally invasive surgery for pulmonary metastasis of sarcoma.
The Journal of thoracic and cardiovascular surgery
Optimized breast MRI functional tumor volume as a biomarker of recurrence-free survival following neoadjuvant chemotherapy.
Journal of magnetic resonance imaging : JMRI
High-resolution diffusion-weighted imaging for the separation of benign from malignant BI-RADS 4/5 lesions found on breast MRI at 3T.
Journal of magnetic resonance imaging : JMRI
Risk of thyroid cancer based on thyroid ultrasound imaging characteristics: results of a population-based study.
JAMA internal medicine
Association between body composition and frailty among prevalent hemodialysis patients: a US Renal Data System special study.
Journal of the American Society of Nephrology : JASN
High resolution in vivo characterization of apparent diffusion coefficient at the tumor-stromal boundary of breast carcinomas: a pilot study to assess treatment response using proximity-dependent diffusion-weighted imaging.
Journal of magnetic resonance imaging : JMRI
Depressive symptoms in Chinese-American subjects with cognitive impairment.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Changes in serum inflammatory markers are associated with changes in apolipoprotein A1 but not B after the initiation of dialysis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
High-resolution diffusion-weighted imaging for monitoring breast cancer treatment response.
Academic radiology
Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans.
Proceedings of the National Academy of Sciences of the United States of America
Behaviour, physiology and experience of pathological laughing and crying in amyotrophic lateral sclerosis.
Brain : a journal of neurology
The relationship between Gulf War illness, brain N-acetylaspartate, and post-traumatic stress disorder.
Military medicine
Spatially extended FMRI signal response to stimulus in non-functionally relevant regions of the human brain: preliminary results.
The open neuroimaging journal
Bayesian decision analysis for choosing between diagnostic/prognostic prediction procedures.
Statistics and its interface
In vivo magnetic resonance imaging and optical imaging comparison of viable and nonviable mesenchymal stem cells with a bifunctional label.
Molecular imaging
A statistical method (cross-validation) for bone loss region detection after spaceflight.
Australasian physical & engineering sciences in medicine
In vivo 3.0-tesla magnetic resonance T1rho and T2 relaxation mapping in subjects with intervertebral disc degeneration and clinical symptoms.
Magnetic resonance in medicine
The Alzheimer's Disease Neuroimaging Initiative: Annual change in biomarkers and clinical outcomes.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Comparing 3 T and 1.5 T MRI for tracking Alzheimer's disease progression with tensor-based morphometry.
Human brain mapping
Bayesian k -space-time reconstruction of MR spectroscopic imaging for enhanced resolution.
IEEE transactions on medical imaging
ASL perfusion MRI predicts cognitive decline and conversion from MCI to dementia.
Alzheimer disease and associated disorders
Quantitative metabolic profiles of 2nd and 3rd trimester human amniotic fluid using (1)H HR-MAS spectroscopy.
Magma (New York, N.Y.)
Evidence for ongoing brain injury in human immunodeficiency virus-positive patients treated with antiretroviral therapy.
Journal of neurovirology
K-Bayes reconstruction for perfusion MRI II: modeling and technical development.
Journal of digital imaging
T2-Weighted endorectal magnetic resonance imaging of prostate cancer after external beam radiation therapy.
International braz j urol : official journal of the Brazilian Society of Urology
K-Bayes reconstruction for perfusion MRI. I: concepts and application.
Journal of digital imaging
Identify fracture-critical regions inside the proximal femur using statistical parametric mapping.
Bone
Body mass index and magnetic resonance markers of brain integrity in adults.
Annals of neurology
Abnormal N-acetylaspartate in hippocampus and anterior cingulate in posttraumatic stress disorder.
Psychiatry research
Effects of Alzheimer disease on fronto-parietal brain N-acetyl aspartate and myo-inositol using magnetic resonance spectroscopic imaging.
Alzheimer disease and associated disorders
Age effects on atrophy rates of entorhinal cortex and hippocampus.
Neurobiology of aging
White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophy.
Neurobiology of aging
Summarizing complexity in high dimensions.
Physical review letters
Comparisons between global and focal brain atrophy rates in normal aging and Alzheimer disease: Boundary Shift Integral versus tracing of the entorhinal cortex and hippocampus.
Alzheimer disease and associated disorders
A method for determining venous contribution to BOLD contrast sensory activation.
Magnetic resonance imaging