
Neurologist
+1 415 353-2311
Dr. Ostrem is a neurologist at UCSF and serves as Medical Director and Division Chief of the Movement Disorders and Neuromodulation Center. She specializes in treating Parkinson’s disease, dystonia, essential tremor, Huntington’s, Lewy body dementia, and spasticity, using advanced therapies like deep brain stimulation. Her research focuses on improving DBS technology, telehealth care, palliative approaches, and experimental treatments.
Publications
Will adaptive deep brain stimulation for Parkinson's disease become a real option soon? A Delphi consensus study.
NPJ Parkinson's disease
Automated Imaging Differentiation for Parkinsonism.
JAMA neurology
Lessons Learned from the ADAPT-PD Clinical Trial: Programming adaptive deep brain stimulation in the clinic.
Parkinsonism & related disorders
Psilocybin therapy for mood dysfunction in Parkinson's disease: an open-label pilot trial.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Local Field Potential Circadian Patterns During Adaptive Deep Brain Stimulation (S32.007).
Neurology
Engaging dystonia networks with subthalamic stimulation.
Proceedings of the National Academy of Sciences of the United States of America
Neural Oscillations Inform Deep Brain Stimulation For Cognitive And Motor Symptoms In Parkinson’s Disease.
Brain stimulation
Technical challenges in developing chronic adaptive deep brain stimulation for Parkinson’s disease.
Brain stimulation
Sustained Clinical Benefit of Adaptive Deep Brain Stimulation in Parkinson's Disease Using Gamma Oscillations: A Case Report.
Movement disorders : official journal of the Movement Disorder Society
Clinically Implemented Sensing-Based Initial Programming of Deep Brain Stimulation for Parkinson's Disease: A Retrospective Study.
Neuromodulation : journal of the International Neuromodulation Society
Parkinson's Disease. Reply.
The New England journal of medicine
Sensing data and methodology from the Adaptive DBS Algorithm for Personalized Therapy in Parkinson's Disease (ADAPT-PD) clinical trial.
NPJ Parkinson's disease
Adaptive Deep Brain Stimulation in Parkinson's Disease: A Delphi Consensus Study.
medRxiv : the preprint server for health sciences
Chronic adaptive deep brain stimulation versus conventional stimulation in Parkinson's disease: a blinded randomized feasibility trial.
Nature medicine
Parkinson's Disease.
The New England journal of medicine
Elevated Mood Induced by Subthalamic Nucleus Deep Brain Stimulation: A Video-Recorded Case Report.
Tremor and other hyperkinetic movements (New York, N.Y.)
Interpretable video-based tracking and quantification of parkinsonism clinical motor states.
NPJ Parkinson's disease
Engaging dystonia networks with subthalamic stimulation.
medRxiv : the preprint server for health sciences
Extended-release amantadine for OFF-related dystonia in Parkinson's disease.
Parkinsonism & related disorders
Mapping dysfunctional circuits in the frontal cortex using deep brain stimulation.
Nature neuroscience
Mapping Dysfunctional Circuits in the Frontal Cortex Using Deep Brain Stimulation.
medRxiv : the preprint server for health sciences
Personalized chronic adaptive deep brain stimulation outperforms conventional stimulation in Parkinson's disease.
medRxiv : the preprint server for health sciences
ID: 197707 Quality-of-Life Improvement and Patient's Impression of Change With Use of Directional DBS Therapy for PD.
Neuromodulation Technology at the Neural Interface
Parkinsonism of uncertain clinical significance (PUCS): A proposed new diagnostic entity.
Journal of the neurological sciences
Interactive mobile application for Parkinson's disease deep brain stimulation (MAP DBS): An open-label, multicenter, randomized, controlled clinical trial.
Parkinsonism & related disorders
Preoperative diffusion MRI features relate to longitudinal changes in Parkinson’s medications after DBS.
Brain stimulation
O132 / #543 REAL-WORLD DEEP BRAIN STIMULATION OUTCOMES USING SYSTEMS WITH DIRECTIONALITY AND MULTIPLE INDEPENDENT CURRENT CONTROL TRACK 2: DEEP BRAIN STIMULATION FOR MOVEMENT DISORDERS.
Neuromodulation Technology at the Neural Interface
Automated deep brain stimulation programming with safety constraints for tremor suppression in patients with Parkinson's disease and essential tremor.
Journal of neural engineering
Benefits and Risks of a Staged-Bilateral VIM Versus Unilateral VIM DBS for Essential Tremor.
Movement disorders clinical practice
Enhancing Clinical Information Display to Improve Patient Encounters: Human-Centered Design and Evaluation of the Parkinson Disease-BRIDGE Platform.
JMIR human factors
FV 1 Segregating the prefrontal cortex by means of deep brain stimulation.
Clinical Neurophysiology
Prefrontal Physiomarkers of Anxiety and Depression in Parkinson's Disease.
Frontiers in neuroscience
Embedded adaptive deep brain stimulation for cervical dystonia controlled by motor cortex theta oscillations.
Experimental neurology
Elevated Mood States in Patients With Parkinson's Disease Treated With Deep Brain Stimulation: Diagnosis and Management Strategies.
The Journal of neuropsychiatry and clinical neurosciences
Long-term wireless streaming of neural recordings for circuit discovery and adaptive stimulation in individuals with Parkinson's disease.
Nature biotechnology
Moving From Wired to Wireless Brain Stimulation to Treat Movement Disorders: Are We Breaking Ground?
Movement disorders : official journal of the Movement Disorder Society
Therapeutic Advances in Movement Disorders.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Thalamic deep brain stimulation for acquired dystonia in children and young adults: a phase 1 clinical trial.
Journal of neurosurgery. Pediatrics
Treatment of Post-Hypoxic Myoclonus using Pallidal Deep Brain Stimulation Placed Using Interventional MRI Methods.
Tremor and other hyperkinetic movements (New York, N.Y.)
Study design and rationale for an international study of DBS for movement disorders.
Parkinsonism & related disorders
Eight cylindrical contact lead recordings in the subthalamic region localize beta oscillations source to the dorsal STN.
Neurobiology of disease
Structural connectivity predicts clinical outcomes of deep brain stimulation for Tourette syndrome.
Brain : a journal of neurology
Secondary Worsening Following DYT1 Dystonia Deep Brain Stimulation: A Multi-country Cohort.
Frontiers in human neuroscience
Phenomenology and Management of Subthalamic Stimulation-Induced Dyskinesia in Patients With Isolated Dystonia.
Movement disorders clinical practice
Surgical Treatment of Parkinson Disease.
Neurologic clinics
Cerebellar Deep Brain Stimulation for Acquired Hemidystonia.
Movement disorders clinical practice
Recommendations for Deep Brain Stimulation Device Management During a Pandemic.
Journal of Parkinson's disease
The Impact of Deep Brain Stimulation on Sleep in Parkinson's Disease: An update.
Journal of Parkinson's disease
Pallidal Thermolesion Unleashes Gamma Oscillations in the Motor Cortex in Parkinson's Disease.
Neurosurgery
Washout of chronic therapeutic deep brain stimulation increases cortical phase-amplitude coupling.
Parkinsonism & related disorders
Patient Experience with Rechargeable Implantable Pulse Generator Deep Brain Stimulation for Movement Disorders.
Stereotactic and functional neurosurgery
THE TABCAT BRAIN HEALTH ASSESSMENT QUICKLY AND ACCURATELY DETECTS LEVEL II MILD COGNITIVE IMPAIRMENT IN PARKINSON’S DISEASE BY MDS TASK FORCE CRITERIA.
Alzheimer's & Dementia
Telepsychiatry for patients with movement disorders: a feasibility and patient satisfaction study.
Journal of clinical movement disorders
Image-based analysis and long-term clinical outcomes of deep brain stimulation for Tourette syndrome: a multisite study.
Journal of neurology, neurosurgery, and psychiatry
Ages at Onset of Anxiety and Depressive Disorders in Parkinson's Disease.
The Journal of neuropsychiatry and clinical neurosciences
Effect of levodopa on electroencephalographic biomarkers of the parkinsonian state.
Journal of neurophysiology
Psychopharmacology for Patients with Parkinson’s Disease and Deep Brain Stimulation: Lessons Learned in an Academic Center.
Current Psychopharmacologye
Pallidal thermolesion unleashes gamma oscillations in the motor cortex in Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society
An Acute Randomized Controlled Trial of Noninvasive Peripheral Nerve Stimulation in Essential Tremor.
Neuromodulation : journal of the International Neuromodulation Society
Deep Brain Stimulation for Fluctuations and Dyskinesia in Parkinson’s Disease.
Therapy of Movement Disorders
Long-Term Outcomes of Bilateral Pallidal Deep Brain Stimulation for X-Linked Dystonia and Parkinsonism.
Stereotactic and functional neurosurgery
Cortical Potentials Evoked by Subthalamic Stimulation Demonstrate a Short Latency Hyperdirect Pathway in Humans.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Benefits and risks of unilateral and bilateral ventral intermediate nucleus deep brain stimulation for axial essential tremor symptoms.
Parkinsonism & related disorders
Automated Deep Brain Stimulation Programming for Tremor.
IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
Effects of deep brain stimulation on rest tremor progression in early stage Parkinson disease.
Neurology
The Subthalamic Nucleus as a Deep Brain Stimulation Target for Dystonia.
Treatment of Dystonia
Adaptive deep brain stimulation for Parkinson's disease using motor cortex sensing.
Journal of neural engineering
Pallidal Deep-Brain Stimulation Disrupts Pallidal Beta Oscillations and Coherence with Primary Motor Cortex in Parkinson's Disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Globus Pallidus Interna or Subthalamic Nucleus Deep Brain Stimulation for Parkinson Disease: A Review.
JAMA neurology
Poster Number: NR 24 Delivery of Psychiatric Care to Patients with Parkinson's Disease Using Telemedicine.
American Journal of Geriatric Psychiatry
Cortical gamma oscillations in isolated dystonia.
Parkinsonism & related disorders
Physiological effects of subthalamic nucleus deep brain stimulation surgery in cervical dystonia.
Journal of neurology, neurosurgery, and psychiatry
Before and after the veterans affairs cooperative program 468 study: Deep brain stimulator target selection for treatment of Parkinson's disease.
Parkinsonism & related disorders
Chronic deep brain stimulation normalizes scalp EEG activity in isolated dystonia.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Pedunculopontine nucleus deep brain stimulation in Parkinson's disease: A clinical review.
Movement disorders : official journal of the Movement Disorder Society
Hemorrhage Detection and Incidence during Magnetic Resonance-Guided Deep Brain Stimulator Implantations.
Stereotactic and functional neurosurgery
Intractable Blepharospasm Treated with Bilateral Pallidal Deep Brain Stimulation.
Tremor and other hyperkinetic movements (New York, N.Y.)
Intractable Blepharospasm Treated with Bilateral Pallidal Deep Brain Stimulation.
Tremor and Other Hyperkinetic Movements
Thalamic deep brain stimulation for orthostatic tremor: A multicenter international registry.
Movement disorders : official journal of the Movement Disorder Society
Parkinson's disease patient preference and experience with various methods of DBS lead placement.
Parkinsonism & related disorders
Chronic multisite brain recordings from a totally implantable bidirectional neural interface: experience in 5 patients with Parkinson's disease.
Journal of neurosurgery
Thalamic DBS with a constant-current device in essential tremor: A controlled clinical trial.
Parkinsonism & related disorders
Clinical Tremor Severity Estimation Using an Instrumented Eating Utensil.
Journal of Parkinson's disease
Subthalamic nucleus deep brain stimulation in isolated dystonia: A 3-year follow-up study.
Neurology
Proceedings of the Fourth Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies.
Frontiers in integrative neuroscience
Problematic Mobile Gaming in Parkinson's Disease: An Impulse Control Disorder for the Smartphone.
Movement disorders clinical practice
Gamma Oscillations in the Hyperkinetic State Detected with Chronic Human Brain Recordings in Parkinson's Disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Subthalamic Nucleus Deep Brain Stimulation in Isolated Dystonia: A 3-Year Follow-Up Study (P1.008).
Neurology
Deep brain stimulator implantation in a diagnostic MRI suite: infection history over a 10-year period.
Journal of neurosurgery
Bilateral Ventral Intermediate Nucleus Thalamic Deep Brain Stimulation in Orthostatic Tremor.
Stereotactic and functional neurosurgery
Pregnancy in a Series of Dystonia Patients Treated with Deep Brain Stimulation: Outcomes and Management Recommendations.
Stereotactic and functional neurosurgery
Intraoperative electrocorticography for physiological research in movement disorders: principles and experience in 200 cases.
Journal of neurosurgery
Subthalamic local field potentials in Parkinson's disease and isolated dystonia: An evaluation of potential biomarkers.
Neurobiology of disease
Effective Interventional Magnetic Resonance Image-Guided Laser Ablations in a Parkinson's Disease Patient with Refractory Tremor.
Movement disorders clinical practice
Electrocorticography reveals beta desynchronization in the basal ganglia-cortical loop during rest tremor in Parkinson's disease.
Neurobiology of disease
Correspondence related to published material title "Deep brain stimulation may reduce the relative risk of clinically important worsening in early stage Parkinson's disease" by Hacker ML and colleague recently published electronically before print.
Parkinsonism & related disorders
Patterns of Cortical Synchronization in Isolated Dystonia Compared With Parkinson Disease.
JAMA neurology
Response.
Journal of neurosurgery
Clinical outcomes using ClearPoint interventional MRI for deep brain stimulation lead placement in Parkinson's disease.
Journal of neurosurgery
Task-related activity in sensorimotor cortex in Parkinson's disease and essential tremor: changes in beta and gamma bands.
Frontiers in human neuroscience
Elevated synchrony in Parkinson disease detected with electroencephalography.
Annals of neurology
Repetitive Transcranial Magnetic Stimulation (rTMS) Therapy in Parkinson Disease: A Meta-Analysis.
PM & R : the journal of injury, function, and rehabilitation
Proceedings of the Second Annual Deep Brain Stimulation Think Tank: What's in the Pipeline.
The International journal of neuroscience
Intraoperative neurophysiology in deep brain surgery for psychogenic dystonia.
Annals of clinical and translational neurology
Therapeutic deep brain stimulation reduces cortical phase-amplitude coupling in Parkinson's disease.
Nature neuroscience
Differential effects of deep brain stimulation target on motor subtypes in Parkinson's disease.
Annals of neurology
Pallidal stimulation for Holmes tremor: clinical outcomes and single-unit recordings in 4 cases.
Journal of neurosurgery
Combining cell transplants or gene therapy with deep brain stimulation for Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society
Interventional MRI-guided deep brain stimulation in pediatric dystonia: first experience with the ClearPoint system.
Journal of neurosurgery. Pediatrics
Effect of subthalamic nucleus deep brain stimulation on dual-task cognitive and motor performance in isolated dystonia.
Journal of neurology, neurosurgery, and psychiatry
Effect of frequency on subthalamic nucleus deep brain stimulation in primary dystonia.
Parkinsonism & related disorders
Neuromodulation for dystonia: target and patient selection.
Neurosurgery clinics of North America
Commentary on "Adaptive deep brain stimulation in advanced Parkinson disease".
Annals of neurology
Focal task-specific lower extremity dystonia associated with intense repetitive exercise: a case series.
Parkinsonism & related disorders
203 Application Accuracy of a Second Generation Interventional MRI Stereotactic Platform.
Neurosurgery
Predictive factors of outcome in primary cervical dystonia following pallidal deep brain stimulation.
Movement disorders : official journal of the Movement Disorder Society
Subthalamic nucleus neurons are synchronized to primary motor cortex local field potentials in Parkinson's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Use of pallidal deep brain stimulation in postinfarct hemidystonia.
Stereotactic and functional neurosurgery
Exaggerated phase-amplitude coupling in the primary motor cortex in Parkinson disease.
Proceedings of the National Academy of Sciences of the United States of America
Clinical outcomes of PD patients having bilateral STN DBS using high-field interventional MR-imaging for lead placement.
Clinical neurology and neurosurgery
Multichannel Electromyographic Mapping to Optimize OnabotulinumtoxinA Efficacy in Cervical Dystonia.
Tremor and Other Hyperkinetic Movements
Multichannel Electromyographic Mapping to Optimize OnabotulinumtoxinA Efficacy in Cervical Dystonia.
Tremor and other hyperkinetic movements (New York, N.Y.)
Weight change after globus pallidus internus or subthalamic nucleus deep brain stimulation in Parkinson's disease and dystonia.
Stereotactic and functional neurosurgery
Acute effects of thalamic deep brain stimulation and thalamotomy on sensorimotor cortex local field potentials in essential tremor.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Oscillations in sensorimotor cortex in movement disorders: an electrocorticography study.
Brain : a journal of neurology
Development of Parkinson's disease in patients with Narcolepsy.
Journal of neural transmission (Vienna, Austria : 1996)
1.290 LONG-TERM NEUROPSYCHOLOGICAL OUTCOMES OF SUBTHALAMIC NUCLEUS (STN) DEEP BRAIN STIMULATION (DBS) IN PRIMARY CRANIAL CERVICAL DYSTONIA (CCD).
Parkinsonism & related disorders
Deep brain stimulation in children: experience and technical pearls.
Journal of neurosurgery. Pediatrics
Factors predicting protracted improvement after pallidal DBS for primary dystonia: the role of age and disease duration.
Journal of neurology
Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial.
The Lancet. Neurology
Long-term benefit sustained after bilateral pallidal deep brain stimulation in patients with refractory tardive dystonia.
Stereotactic and functional neurosurgery
Dystonia in neurodegeneration with brain iron accumulation: outcome of bilateral pallidal stimulation.
Brain : a journal of neurology
Subthalamic nucleus deep brain stimulator placement using high-field interventional magnetic resonance imaging and a skull-mounted aiming device: technique and application accuracy.
Journal of neurosurgery
Overview of common movement disorders.
Continuum (Minneapolis, Minn.)
A child with progressive dystonia, dysarthria, and spasticity.
Reviews in neurological diseases
Pedunculopontine nucleus deep brain stimulation in a patient with primary progressive freezing gait disorder.
Stereotactic and functional neurosurgery
P2.113 Multicenter, randomized, double-blind, sham surgery-controlled study of intraputaminal AAV2-neurturin (CERE-120) for advanced Parkinson's disease (PD).
Parkinsonism & related disorders
The subthalamic nucleus in primary dystonia: single-unit discharge characteristics.
Journal of neurophysiology
Physiological identification of the human pedunculopontine nucleus.
Journal of neurology, neurosurgery, and psychiatry
Surgical repositioning of misplaced subthalamic electrodes in Parkinson's disease: location of effective and ineffective leads.
Stereotactic and functional neurosurgery
Fluoroscopic, EMG-guided injection of botulinum toxin into the longus colli for the treatment of anterocollis.
Parkinsonism & related disorders
Induction of bradykinesia with pallidal deep brain stimulation in patients with cranial-cervical dystonia.
Stereotactic and functional neurosurgery
Interventional magnetic resonance guidance of deep brain stimulator implantation for Parkinson disease.
Topics in magnetic resonance imaging : TMRI
Single unit "pauser" characteristics of the globus pallidus pars externa distinguish primary dystonia from secondary dystonia and Parkinson's disease.
Experimental neurology
Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial.
The Lancet. Neurology
Treatment of dystonia with deep brain stimulation.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Neuronal responses to passive movement in the globus pallidus internus in primary dystonia.
Journal of neurophysiology
Pallidal deep brain stimulation in patients with cranial-cervical dystonia (Meige syndrome).
Movement disorders : official journal of the Movement Disorder Society
Chronic stimulation of the posterior hypothalamic region for cluster headache: technique and 1-year results in four patients.
Journal of neurosurgery
Multiple target deep brain stimulation for multiple sclerosis related and poststroke Holmes' tremor.
Stereotactic and functional neurosurgery
Placement of Subthalamic DBS Electrodes in a Radiology Suite Using Interventional MRI.
Proceedings of the Medtronic Forum for Neuroscience and Neuro-Technology 2005
Microelectrode-guided implantation of deep brain stimulators into the globus pallidus internus for dystonia: techniques, electrode locations, and outcomes.
Journal of neurosurgery
Placement of deep brain stimulator electrodes using real-time high-field interventional magnetic resonance imaging.
Magnetic resonance in medicine
Patient Selection and Indications for Surgery.
Surgical Management of Movement Disorders
Spontaneous pallidal neuronal activity in human dystonia: comparison with Parkinson's disease and normal macaque.
Journal of neurophysiology
Disclosing Daydreams versus Real Experiences: Attitudes, Emotional Reactions, and Personality Correlates.
Imagination Cognition and Personality
Microelectrode-guided implantation of deep brain stimulators into the globus pallidus internus for dystonia: techniques, electrode locations, and outcomes.
Neurosurgical focus
Changing patterns of brain activation during maze learning.
Brain research
Modulation of cognition-specific cortical activity by gonadal steroids: a positron-emission tomography study in women.
Proceedings of the National Academy of Sciences of the United States of America
Dextroamphetamine enhances "neural network-specific" physiological signals: a positron-emission tomography rCBF study.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Cognitive activation during PET: a case study of monozygotic twins discordant for closed head injury.
Neuropsychologia
Physiological activation of a cortical network during performance of the Wisconsin Card Sorting Test: a positron emission tomography study.
Neuropsychologia
Is there cognitive decline in schizophrenia? A cross-sectional study.
The British journal of psychiatry : the journal of mental science
Differential effects of prior dominance or subordination experience on conspecific odor preferences in mice.
Physiology & behavior
Effects of eltoprazine hydrochloride on reactivity to conspecific or novel odors and activity.
Pharmacology, biochemistry, and behavior